Cannabinoid receptors and nutrition
A receptor antagonist reduces food intake in animals
In animal experiments with rats the effects of the CB1 receptor antagonist AM 251 on feeding behaviour were investigated. The drug dose-dependently decreased food intake and induced nausea.
Researchers conclude that the antagonist "may reduce food intake in part by inducing nausea or malaise."
see also: Rimonabant/Acomplia
(McLaughlin PJ, et al. Psychopharmacology (Berl) 2005;180(2):286-93.)