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Role of cannabinoid-2-receptor in liver cirrhosis

CB2 receptors were found in liver cells of patients with active cirrhosis, but were absent in normal human liver.

According to new research the cannabinoid receptor CB2 plays an antifibrogenic [1] role in the liver and cannabinoids may help to block the development of liver fibrosis.

Activation of CB2 receptors caused potent antifibrogenic effects, namely, growth inhibition of liver fibrogenic cells and apoptosis. Authors note that their research "highlights the antifibrogenic role of CB2 receptors during chronic liver injury."


Source: Julien B, et al. Gastroenterology 2005;128(3):742-55


[1] fibrinogen is a blood coagulation factor

published Thursday 21 April 2005 08:19