Sublingual administration of cannabinoids
Novel cyclodextrin-containing sublingual formulations of cannabinoids were developed by Finish researchers.
By adding cyclodextrin to THC or CBD their solubility in water was considerably increased.
Sublingual administration of a THC/cyclodextrin complex substantially increased the bioavailability of THC in rabbits.
(Source: Mannila J, et al. Eur J Pharm Sci 2005 Jun 12; [Electronic publication ahead of print] )